The Romans built amphitheaters all across their vast empire, but this is the largest and most important of them all. Its four levels of seats could hold 50,000 spectators for bloody gladiatorial combat and wild animal fights. Drive by the Colosseum for a photostop.

Next, stop at the Trevi Fountain. This massive Baroque extravaganza was built in 1732 and features Neptune, god of the sea, surging forward in his shell-shaped chariot. After lunch, proceed to St. Peter's Square, designed and built by Bernini and visit St. Peter's Basilica. If time permits, you'll have some free time to explore on your own.